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Need Statement: “A way to optimize the process of patient monitoring and…
Need Statement: “A way to optimize the process of patient monitoring and formula adjustment for providers working with neonates on PN in order to reduce the incidence of PN-related toxicity.”
Monitoring
Biochemical/Biological
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Improved assays for liver function to better understand which neonates will be more susceptible to liver complications
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Formula Composition
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Chemical innovation that incorporates solubility w/o compromising other qualities of the formula to prevent Ca2+ and PO32- precipitation
Delivery Methods
New modes of delivery
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Control flow rate of IV, maybe even different rates for individual nutrients
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Method of mimicking activity of under-developed part of the GI tract, allowing for oral delivery
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A slow release sublingual pill that is able to deliver nutrients (may have to alter permeability of the ingredients and/or the mucus membrane)
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Playing with the rate of administration--are there any benefits to pulse-width type administration of nutrients?
Sterility
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Materials science approach to improve sterility of every material involved in the PN assembly process--less porous? antibacterial?
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