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PH BUFFER ISOTONIC SOLUTION, The solution resist change in PH after…
PH BUFFER ISOTONIC SOLUTION
-ve logarithm of base 10
Ph= -log10 [H+]
Sorensen PH Scale -: 1-14
Link Title
1-5 : Acidic
7: Neutral
8-14: Alkaline
Determination - Potentiometric (Discription of PH meter
Colorimetre (PH paper)
TYPE
Weak acid and congugate salt of strong acid
Combination of acid and base
2 Salt (Acid base pair exchange
The ability of buffer to resist change in PH up on addition of small amount of acid or base
Quantitative, Buffer capacity - Amount of acid or base required to change PH of 1 litre buffer by 1 unit
Buffer equation ( Handersen Hassel balch equation)
PH = pka+log [salt][acid]
Application:
1.Determine PH of solution
2.Amount of unionised molecule
Pka
4.Solubility at any PH
Selection of salt for preparation of suitable PH buffer
Larger the buffer capacity more resistance and
Buffer
Buffer application
1.Solubility
Increase at particular PH
e.g Ferric phosphate and borate in acidic media
Colour
Colour of cherry and resberey PH maintain at acid PH Adrenaline 2.5-5, sodium thiosulphate in alkaline, sodium meta bisulphate
3.Patient Comfort
To prevent irritation in parentral
4.Activity
Sodium hypochloride germicidle effect is more at lower PH
Classification
1.Pharmaceutical buffer
2.Biological buffer
The solution resist change in PH after addition of small quantity of acid or base