Increase mobilization of FFA from peripheral tissues

Increased hepatic VLDL secretion and FFA synthesis

Leads to Increase TG rich lipoproteins leading to increase in CETP, and increase in LDL and decrease in ApoA1

Medical therapy (statin, fibrate, Niacin, Cholestyramine)

Increase adipocyte mass -> Increase insulin Resistance

Increase FFA in the liver -> Increase VLDL-C production

Increased pro-inflammatory cytokines that reduce TG clearance

Leads to downregulation of LDL-R and increase in LDL-C

Decrease in hepatic lipase leading to increase in triglycerides

Increase TG and increase risk of pancreatitis and atherosclerosis

Dysfunction can lead to decrease in HDL and Decrease in LCAT

Leads to increase in triglyceride and decreases LPL and clearance

Leads to small dense LDL-C and can make it more atherogenic than large LDL-C

Leads to decrease HDL-C and low Apo-A1, and downregulation of LCAT, impaired maturation, and no anti-oxidative

Albumin falls -> Increase total cholesterol, LDL, triglycerides

Normal or Low HDL-C renal loss of LCATm increased CETP

Excess adiposity, insulin resistance, Lipolysis and FFA release, and Increase VLDL

Impaired VLDL excretion (steatosis, and hepatic TG accumulaton)

Progressing liver disease leads to Decreased total cholesterol and triglycerides due to less lipoprotein synthesis

Accumulation of lipoprotein-X and is not removed by LDL-R and decrease feedback on cholesterol synthesis

Increased total cholesterol and increased LDL with worsening liver disease

HDL in early stage increases and decreases in later stages

Inability to mobilize hepatic glucose during fasting

Hypoinsulinemia and increase release of FFA from adiose tissue

Cortisol mobilizes fuel and increases glucose and FFA

Leads to increase of VLDL and Mild LDL increase

Prolonged high cortisol leads to insulin resistance

Leads to increase VLDL-C and mild increase in TG

May be due to decreased excretion of bile acids and cholesterol

Antiviral medications can increase circulating TG

HIV infection can lead to mild increase in triglycerides, VLDL-C increase, decrease in LDL and HDL

Due to lower TG clearance and increase VLDL-C synthesis

high doses lead to increase in VLDL, LDL and tends to be temporary

Non-selective beta blockers increase triglycerides and decrease HDL

Selective alpha 1 blockers cause decrease in total cholesterol, decrease in triglycerides and increase in HDL-C

Decrease in total cholesterol, Dcrease in LDL, and increase in VLDL and HDL, and increase in triglycerides

Mild increase in LDL and decrease in HDL (typical of oral contraceptive pill)

More effects on lipids if taken orally: HDL decrease, LDL increase and slight decrease in TG (VLDL, CM)

Mobilizes fuel to increase glucose, and FFA -> Increase in VLDL and triglycerides and increased LDL

Increase triglycerides and LDL and increase VLDL production due to protease ihibtiors

Retinoids (increase VLDL, CM), Cyclosporine (Increase LDL), Carbamazepine (increase LDL)