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Renal Disease - Coggle Diagram

- - - - granular IF stained for igA
    - - most common vasculitis in kids
  - - - immune complex, increase cellularity, subendothelial deposits. severe and often leads to ESRD
        
        wire looping of capillaries
        
        granular IF with a "full house"
  - - - anti-glomerular BM antibodies. type II hypersensitivity
        
        linear pattern on IF
        
        One form of type I RPGN is GOODPASTURE SYNDROME
        
        has antibodies to alpha 3 chain of type IV
        collagen (in the GBM and alveoli)
        
        causes hemotypsis and hematuria
        
        associated with HLA-DR2
    - - Immune complex deposition, type III hypersensitivity
        
        causes: PSGN or SLE (DPGN)
    - - pauci immune
      - most patients are ANCA positive , have vasculitis syndrome
- - - - everything looks normal except for effacement of foot processes on electron microsocpy
      - lipids may be seen in the proixmal tubule of the nephron in light mircroscopy
  - - - often progresses to chronic renal failure
  - - - IF shows granular deposits of IgG and C3
        
        subepithelial deposits and spike and dome appearance