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antihistamines - Coggle Diagram
antihistamines
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characteristics
- histamine receptors are constitutively active (always active)
- antihistamines are inverse agonists
inverse agonist
- they produce the opposite effect to the histamine rather than simply blocking the receptors
- the histamine levels go from positive to zero
specific drugs
promethazine
- causes respiratory depressional young children
fexofenadine
- fruit juice inhibit organic anion transporting polypeptides and interfere with absorption
- do not drink 4h before and 1-2 hours after dosing
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