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Fungal Infection - Coggle Diagram

- - - - Thrush
    - - Oesophageal
    - - Candidemia
        Bloodstream infection
- - - - Infection of lungs
      - Candida enter lung
      - Hyphae invade tissue
    - - An aspergilloma is a clump of mold which exists in a body cavity such as a paranasal sinus or an organ such as the lung
      - Mobile
      - Shift seen on CT when pt shifts
    - - Allergic bronchopulmonary aspergillosis is a condition characterised by an exaggerated response of the immune system to the fungus Aspergillus
    - - Asthma is a condition in which your airways narrow and swell and may produce extra mucus
  - - - Specific for Aspergillus
    - - Fungal infections in general
- - - - Periorbital Mucormycosis
      - Pulmonary mucormycosis
- - - - Allylamines
      - Azoles
      - Amorolfine
      - Ciclopirox
    - - Griseofulvin
      - Allylamines
      - Azoles
  - - - Examples
        
        Voriconazole
        
        Posaconazole
        
        Isavuconazole
        
        Fluconazole
      - MOA
        
        Target ergosterol synthesis
      - Fungistatic to yeasts
        
        Fungicidal to moulds
      - Adverse Effects
        
        Live
        
        Drug interactions
        
        Aquired resistance may occur
    - - Examples
        
        Micafungin
        
        Anidulafungin
        
        Caspofungin
      - MOA
        
        Targets Glucan synthesis
      - Fungicidal to yeasts
        
        Fungistatic
      - Adverse Effects
        
        Rarely aquired resistance
    - - Amphotericin B
      - MOA
        
        Ergosterol / polyene complex ihibits cell membrane function
      - Fungicidal to yeast and moulds
        
        ADR
      - Adverse Effects
        
        Nephrotoxic
    - - Flucytosine
      - MOA
        
        Targets DNA / RNA synthesis