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Central Nervous System Drugs - Coggle Diagram

- - - - Mechanism: Block nerve from signaling brain.
      - Prescribe: Muscle spasm, muscle strains, injuries.
      - Side effect: Drowsiness, dizziness, dry mouth, blurred vision, constipation.
      - Cyclobenzaprine, methocarbamol, metaxalone, dicyclomine (gut antispasmodic to treat irritable bowel syndrome - IBS).
    - - Mechanism: Block nerve signaling from spinal cord. Act directly on muscle skeleton to relax spasm.
      - Prescribe: Manage muscle spasticity*.
      - Side effect: Drowsiness, dizziness, weakness, fatigue, muscle weakness.
      - Baclofen, tizanidine, dantrolene.
- - - - Mechanism: Stimulate and increase the frequency of opening of the GABA-A receptor C1-channel in the presence of GABA. Increase the influx of chloride ions into the neuron.
      - Side effect: Sedation, dizziness, tolerance and dependence, cognitive impairment, tremor.
      - Clobazam, clonazepam, diazepam, lorazepam, midazolam.
    - - Mechanism: Stimulate and increase the duration of opening of the GABA-A receptors with even very low concentration of GABA. Increase the influx of chloride ions into the neuron.
      - Side effect: Somnolence, sedation, tolerance and dependence, induce of hepatic enzyme, cognitive impairment.
      - Phenobarbital, primidone (pre-drugs of phenobarbital), pentobarbital.