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PITUITARY GLAND, ACROMEGALY, ACTIONS OF GROWTH HORMONE - Coggle Diagram
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ACROMEGALY
INTRODUCTION
- means enlargement of acral (peripheral) parts of the body
- due to hypersecretion of GH after fusion of epiphysis
ETIOLOGY
- due to tumor of somatotrophs of anterior pituitary
- tumor of somatotrophs is associated with proliferation of lactotrophs so PRL secretion is also increased
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FEATURES
- enlargement of acral parts of the body esp. hands and feet
- prognathism (lower jaw protrusion)
- acromegalic face (overgrowth of malar, frontal and facial bones,)
- inc in amount of body hair
- osteoarthritis - due to skeletal changes
- glucose intolerance
- hirsutism
- gynecomastia & lactation
- visual field changes (bitemporal hemianopia)
- kyphosis due to improper vertebral growth
- inc sympathetic activity causes hypertension asd sweating
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visual defects - pituitary tumor enlarges sella turcica and compresses on optic chiasma. This also causes headache
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MANAGEMENT - diagnosis by typical clinical presentation, demonstration of pituitary tumor by CT scan or MRI, demonstration of high plasma GH level. surgical removal of tumor is the best option to cure the disease
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