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MIK SK 1 FEVER, Anamnesis, 5130021054_Kamila Ni'ami Permatasari, Dr.dr…

- - - - The Icteric stage
        
        Characterized by dark urine, the appearance of jaundice, clay-colored stools, and an enlarged liver
      - The Recovery stage
        
        Marked by the disappearance of the jaundice and the reduction of other accompanying symptoms.
      - Prodromal stage
        
        The virus will reproduce and release chemicals to which the body will respond.
        
        This body response is characterized by the appearance of symptoms such as fever, fatigue, nausea, vomiting, skin rashes and joint pain
        
        will subside when jaundice appears.
    - - spreads to the liver
        
        infects hepatocytes and multiplies
  - - - Ribavirin
      - Protease Inhibitor
        
        DAA (Direct Acting Anti Virus)
        
        NS5A Protein Inhibitor
        
        Analog NS5B Polymerase Inhibitor
        
        NS3/4A protease inhibitor
      - Interferon Alfa
        
        Pegylated interferon alfa (PEG-IFN alfa)
    - - Genotypes I & IV
        
        therapy is given for 48 weeks
      - Genotypes II & III
        
        therapy is given for 24 weeks
    - - Hepatitis C without cirrhosis (8-12 weeks)
        
        Sofosbuvir 400mg + Daclatasvir 60mg = 12 weeks
        
        Sofosbuvir 400mg + Velpatasvir 100mg = 12 weeks
        
        Glecapevir 300mg + Pibrentasfir 120mg = 8 weeks
      - Hepatitis C with cirrhosis (12-24 weeks):
        
        Sofosbuvir 400mg + Velpatasfir 100mg = 12 weeks
        
        Sofosbuvir 400mg + Daclastavir 60mg = 24 weeks
        
        Glecapavir 300mg + Pibrentasvir 120mg = 12 weeks
  - - - The immune system reacts to infection by creating an immune response. However, HCV has the ability to evade the immune system in several ways, allowing it to persist in the body for long periods of time.
    - - An excessive immune response and chronic inflammation in the liver are the main features of hepatitis C. This can lead to hepatocyte damage and the formation of scar tissue (fibrosis).
    - - After entering the body, HCV targets hepatocytes, the main liver cells. The virus enters the hepatocytes and begins to replicate in them.
    - - If HCV infection is left untreated, fibrosis can progress to cirrhosis, which is an advanced stage of liver damage. Cirrhosis can cause serious complications such as liver failure and liver cancer (hepatocellular carcinoma).
    - - HCV enters the human body through contact with infected blood, such as sharing needles among drug users, past unsafe blood transfusions, or unsterile medical practices.
    - - People with cirrhosis due to hepatitis C have a higher risk of developing liver cancer, especially hepatocellular carcinoma.
  - - - Ex: razors, toothbrushes & nail clippers
    - - using condoms and not changing sexual partners
    - - consuming balanced nutritious food & exercising regularly
    - - after outdoor activities & before eating
- - - - IgM anti HCV (+)
      - RNA HCV (+)
      - Anti-HCV (+)
    - - Anti HDV (+)
      - RNA HDV (+)
    - - Anti HAV IgM (-),anti HAV IgG (+)
      - Anti HAV IgM (-),anti HAV IgG (+)
      - Anti HAV IgM (-),anti HAV IgG (+)
      - Anti HAV IgM (+), anti HAV IgG (-)
    - - HBV DNA ( Viral load ) (+)
      - HBsAg (+)
      - Anti HBs (+)
    - - Anti HAV IgM (-),anti HAV IgG (+)
      - Anti HAV IgG (+)
      - IgM dan IgG anti HEV (+)
      - IgM dan IgG anti HEV (-)
  - - - High Fever
      - Sweating
      - Shivering