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1.24.1.15 - Haemostasis - Coggle Diagram

- - - - transforming growth factor beta
      - platelet derived growth factor
      - insulin like growth factor
  - - - calcium
      - serotonin
      - contain ADP and ATP
    - - similar to lysosymes
      - contain hydrolytic enzymes
    - - contents involved in clot resorption
- - - - serotonin
      - ADP
      - platelet activating factor
  - - - effective vasodilation
- - - - injury exposes TF-bearing cell to flowing blood
      - small amount of FIXa and thrombin generated
    - - thrombin activates platelets (exposing PS)
      - vWF released
      - leads to activation of FXI, FVIII, FV
    - - factrs assemble on the activated platelet to form intrinsic tenase
      - prothrombinase complex forms and results in a burst of thrombin generation directly on the platelet
      - results in FXa generation on the platelet surface
- - - - abnormal platelet function
    - - abnormally low plateelt count
      - decreased production
      - increased destruction/consumption
  - - - haematocytometer
      - automated cell count
      - blood smear
  - - - 2ml blood in ACT tube containing contact activator
      - warm
      - check for clot formation every 5-10 seconds
      - recod time that clot forms
      - check reference range for the tube type
  - - - assess the ability of added thrombin to convert fibrinogen - fibrin