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Not so mellow yellow, The target of treating liver disease, if:, Double…

- - - - blood-borne
    - - enveloped ssRNA
  - - - Feco-oral
    - - Non-enveloped ssRNA
- - - - due to portal
        
        portal hypertension
      - connecting the portal and systemic circulations.
  - - - anastomosis varices
        
        Umbilicus
        
        caput medusa
        
        Esophagus
        
        bleeding
        
        Stomach
        
        bleeding
        
        Rectum
        
        hemorrhoids
        
        bleed
  - - - 16 cm in the midclavicular line.
    - - (hepatosplenomegaly)
  - - - irreversible
      - major contrubioter
        
        Stellate Cells
    - - Hyperammonemia
      - Jaundice
      - Hypoglycemia
      - Coagulopathy
      - Hypoalbuminemia
      - Gynecomastia
      - and more
      - edema & Ascites
    - - liver biopsy
      - Imaging
        
        CT
        
        MRI
        
        ultrasound
      - Clinical diagnosis
- - - - made of
        
        lobules
        
        Has central vein
- - - - Ribavirin
      - Sofosbuvir
    - - Entecavir
      - Tensfovir
      - Lamivudine
  - - - Have longer half-life
  - - - Examples
        
        Voilaprevir
        
        Simeprevir
    - - Examples
        
        Elbasvir
        
        Ledipasvir
    - - Examples
        
        Sofobuvir
        
        Dasabuvir
- - - - Glycogenesis
        
        Glycogenolysis
        
        Gluconeogenesis
    - - Oxidizing triglycerides
        
        Breaking down fatty acids
        
        producing cholesterol
    - - synthesizing plasma proteins
        
        Deamination and transamination of amino acids
        
        removing ammonia
  - - - Chemically modifying compounds for excretion.
  - - - For emulsifying fats.
        
        Eliminating metabolic wastes
        
        gallbladder stores bile
- - - - Hemolytic Anemia
      - Blood transfusion
      - Hemolytic Drugs
      - Ineffective erythropoiesis
      - Resorption of blood from internal hemorrhage
    - - Hepatitis
      - cirrhosis
      - Gilbert syndrome
      - Crigler-Najjar syndrome
      - Dubin-Johnson syndrome
      - Rotor syndrome
    - - Calculous chlocystitis
      - Carcinoma of the head of the pancrease
      - Pancreatic edema
- - - - Acute H.
        
        Occure less than 6 monthes
        
        present as
        
        jaundice
        
        dark urine
        
        fever
        
        malaise
        
        elevated liver enzymes (ALT˃ AST)
        
        nausea
    - - The portal infiltrates are dense & prominent
        
        can progress to
- - - - Survival
- - - - Living with someone with HIV
        
        higher risk