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Beta-Lactam resistance bacteria - Coggle Diagram
Beta-Lactam resistance bacteria
introduction
Mechanism
production of b-lactamase
Destroy b-mactam
Production of an altered PBP with a low affinity for most B-lactam antibiotics
Regulation of b-lactam entry and efflux
Bacteria
Beta-lactam resistance Acinetobacter baumannii (Developed)
Gram -
Treatment
Beta-lactam resistance Staphylococcus aureus (Developed)
Treatment
Lefamulin (2019)
What mechanism to against?
Omadacycline (2018)
What mechanism to against
Gram +
Keypoint
New advance SMW
new developed resistance is best
advanced SMW
Beta-lactam +Beta-lactase inhibitors
ceftolozane–tazobactam, ceftazidime–avibactam, imipenem–relebactam and meropenem–vaborbactam
Ref
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-023-01153-6#:~:text=2%2C3%5D.-,Over%20the%20recent%20years%2C%20four%20innovative%20β%2Dlactam%2Fβ,treatment%20of%20certain%20DTR%2DGNB
Inhibit protein synthesis
Lefamulin and omadacycline for MRSA
binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
Nanoparticle ZnO NPs
Ref
https://www.mdpi.com/1420-3049/27/8/2489
elevate the level of reactive oxygen species (ROS) and malondialdehyde in the bacterial cells as membrane lipid peroxidation.
diminish the permeable membrane, denature the intracellular proteins, cause DNA damage, and cause membrane leakage.
Beta-lactam Resistant Gram-negative food pathogens, such as Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Klebsiella pneumoniae, and Proteus mirabilis,
Inhibitor of quorum sensing (QS) systems
Antimicrobial peptide
Multi-killing mechanism