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HPA Integration (Adenohypophysis) - Coggle Diagram
HPA Integration (Adenohypophysis)
Hypothalamo-Hypophyseal Portal
Hypothalamic Neurosecretory Cells Synthesize & Release Hormones in Cell Bodies
Hormones Packaged in Vesicles Reach Axon Terminal
Nerve Impulses Stimulate Vesicles to Undergo Exocytosis & Diffuse into Primary Plexus (Capillaries)
Hormones Flow through Portal Vein into Secondary Capillaries
Hormones Go into Secondary Plexus (Capillaries), Drain into Anterior Hypophyseal Veins, into General Circulation
Direct Rout e Allows Hypothalamic Hormones Act Immediately on Adenohypophysis Cells
9 Hypothalamic Hormones
Paraventricular
TRH
CRH
Preoptic Area
GnRH
Arcuate
GnRH
GHRH/Somatocrinin
PIH/Dopamine
Ventral
PRH
GHIH/Somatostatin
Dorsomedial
TRH
6 Adenohypophysis Hormones
3 Axes
Gonadotropins
Hypothalamic GnRH Acts on Anterior Pituitary --> Release FSH & LH --> Acts on Gonads --> Increased --> Negative Feedback
FSH - Stimulate Growth of Ovarian Follicles, Secretion of Estrogen (in Female), Stimulate Sperm Production (in Male)
LH - Ovulation, Maintenance of Corpus Luteum (in Female), Testosterone Secretion & Growth of Thyroid Gland (in Male)
Inhibin - Inhibit GSH Secretion
Sex Steroid (Estrogen/Testosterone) - Suppress LH Secretion
Growth Hormone
Thyroid Hormone
Prolactin