Please enable JavaScript.

Coggle requires JavaScript to display documents.

Cardiovascular Disease - Coggle Diagram

- - - - A. Asses aspiring risk
      - B. Blood pressure
      - C. Cholesterol
      - C. Cigareettes
      - D. Diet and Weight
      - D. Diabetes
      - E. Exercise
- - - - Bile acids
      - Steroid hormones
    - - Integrity of cell membranes
  - - - Shelll of phospholipids and apoproteins
      - Hydrophobic core
- - - - Inhibit HMG co A REductase
        
        Upregukate LDL receptors
        
        Reducation of VLV sythnesis
        
        Pleiotropic effects
    - - Simvastatin
        
        Pravastatin
        3. Atorvastatin - High intensity
        
        Rosuvastatin - High intesnity
    - - Mypothay
      - Hepatotoxicity
        
        All statins can cause hepatotoxicity- dose related
        
        Most likely during first few months of Rx
        
        Controlled trials: persistent elevations of transaminases > 3 times ULN, uncommon (< 1%)
        
        In general, avoid Statin if increases in ALT and AST > 3 x ULN
        
        Altered LFT’s usually decrease to pre- treatment levels upon discontinuation