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Adrenal Gland - Coggle Diagram

- - - - Pituitary gland tumour: Pituitary Adenoma
        
        Cushing Disease
        
        Pituitary gland making excess ACTH
      - Ectopic ACTH
        
        Small cell lung cancer
        
        ACTH coming from other than the pituitary gland in the body
      - Adrenal Gland Tumor
        
        Adrenal adenoma and adrenal carcinoma
        
        causes the other adrenal gland to shrink in size while the tumor gland grows in size (Bc of negative feedback)
    - - taking steroid medications
        
        mimics cortisol actions in the body. instils negative feedback to brain. causes adrenal gland to shrink because zona fasciulata is the widest part of the adrenal cortex
  - - - Trigger mineralcorticoid effect by binding on the molecules that are suppose to supress/transport mineralcorticcoid, this results in an increase of free aldosterone in the blood
  - - - Determining the cause of endogenous cortisol production
        
        Give high dose of dexamthasone if there are high ACTH levels
    - - It is a synthetic form of glucocorticoid
  - - - Sudden withdrawal is dangerous as the adrenal gland might be atropic (due to the shrinkage) and it will lead to an adrenal crisis
- - - - Cortisol
        
        Effects
        
        Part of circadian rhythm
        
        peaks in the morning
        
        (+) gluconeogenesis
        
        (+) proteolysis
        
        (+) Lipolysis
        
        A BIG FIB
        
        (-) Immunity response
        
        (+) Blood pressure
        
        (+) Insulin Resistance
        
        Cortisol is a stress hormone, hence when your body is in stress your body needs to supply more glucose to prepare for the stress
        
        Cortisol circulates in the blood in protein-bound form (95%) and freely (5%)
        
        This free form cortisol is the active form
        
        They are bound to plasma protein alpha-globulin called transcortin or corticosteroid binding globulin (CBG)
        
        cortisol is also made by the zona reticularis a little bit
- - - - Glomerulosa in Adrenal cortex secretes cortisol