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Classification of jaundice, Ana Maria Romero y Julieth Puentes - Coggle…
Classification of jaundice
PRE-HEPATIC
There is excessive red cell breakdown which overwhelms the liver’s ability to conjugate bilirubin. This causes an unconjugated hyperbilirubinaemia.
Causes
Haemolytic anaemia
Gilbert’s syndrome
Criggler-Najjar syndrome
POST-HEPATIC
This refers to obstruction of biliary drainage. The bilirubin that is not excreted will have been conjugated by the liver, hence is a conjugated hyperbilirubinemia.
Causes
Intra-luminal causes
Gallstones
Mural causes
Cholangiocarcinoma, strictures, or drug-induced cholestasis
Extra-mural causes
Pancreatic cancer or abdominal masses (e.g. lymphomas)
HEPATOCELLULAR (Intrahepatic)
There is dysfunction of the hepatic cells. This means the liver loses the ability to conjugate bilirubin. This leads to both unconjugated and conjugated bilirubin in the blood or a ‘mixed picture’.
Causes
Alcoholic liver disease
Viral hepatitis
Iatrogenic, e.g. medication
Hereditary haemochromatosis
Autoimmune hepatitis
Primary biliary cirrhosis or primary sclerosing cholangitis
Hepatocellular carcinoma
Ana Maria Romero y Julieth Puentes