Please enable JavaScript.
Coggle requires JavaScript to display documents.
Intravitreal 3D printed Implants - Coggle Diagram
Intravitreal 3D printed Implants
Design
Size
Gauge 30 (ID: 159um) up to 27 TW (ID: 241um)
Mechanisms
hooking
Folding
Drug Release
Scaffold with API Body
entire implant out of API-Resin
Scalability
Pipetting machines
Material
Printing Resins
Nanoscribe
other formulations
Resins with API
API Stability in matrix
Release Profiles
self-formulated
PEG-DA
Dissolution
Different Dissolution time of scaffold and API material
No Microparticles! FDA
OLMA1
faster degradation
OLMA2
Model Drug
Recommendation of PTDE-P Drug Delivery Circle
Lucentis/Ranibizumab
good knowledge base, info available
comparability with PDS
evtl. Susvimo
Large molecules
small molecules
Testing
Vitreous performance Model
too much atm. according to drug delivery circle
PBS recommended
Testing Temperature 34°C
established PBS additives
Drug Release Studies
well established
Testing of the hooking system?
injectability?
loading of the implant to syringe?
IEC (ion exchange chromatography)
SEC (size exclusion chromatography)
Printing
Two materials