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Hematopoiesis, CD4+ t cells, Innate lymphoid cells, dendritic cells -…
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CD4+ t cells
Treg
Once an infection is terminated, Treg cells closes down the effector CD4 and CD8 T-cell responses to prevent further inflammation and tissue damage
Th17
activates macrophages to increase phagocytosis and to kill those phagocytosed pathogens that resist the usual processes of intracellular degradation
Th1
activates macrophages to increase phagocytosis and to kill those phagocytosed pathogens that resist the usual processes of intracellular degradation
Th2
subset responds to parasite infections by secreting cytokines that activate mast cells, basophils, and eosinophils
Tfh
Cytokines secreted by TFH cells induce the differentiation of antigen-activated B cells to become antibody-secreting plasma cells
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Innate lymphoid cells
NK cell
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transcriptional and/or phenotypical characteristics: circulate in blood, absence of MCHI, cytotoxic function compared to ILCs. Similar to ILC1
effector molecules produced: IFN-γ, granzymes, perforin
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Dependent on TF T-bet and EOMES for lineage specification, development and function.
function: Cell-mediated cytotoxicity Intracellular infections Viruses and some bacteria, recognize and kill virus infected cells and tumour cells.
ILC 1
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respondence: intracellular pathogens (virus/tumours), intracellular microbes
transcriptional and/or phenotypical characteristics: resident in tissues. receptors: NFIL3, RUNX3
effector molecules produced: IFN-γ, granzymes, perforin
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Dependent on TF T-bet for lineage specification, development and function.
ILC3
transcriptional and/or phenotypical characteristics: resident in tissues, mostly intestinal mucosal
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ILC2
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transcriptional and/or phenotypical characteristics: resident in tissues, mainly respiratory. CRTH2 + CD161hi
effector molecules produced: IL-4, IL-5, IL-13
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most important functions: lysis of stressed/infected cells, release of cytokines to activate macrophages/T cells
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