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Dendritic cells, Differentiation pathway, Differentiation pathway,…
Dendritic cells
Plasmacytoid DC
Functions
TLR9
Detect unmethylated CpG motifs in dsDNA
respond to tumors
TLR7
Detect viral ssDNA
Present in blood and lymph
Morphology
Star-shaped morphology
Eccentric nucleus
Promint endoplasmic reticulum and Golgi
Markers
CD45ra
CD123
CD303
CD304
No CD11b & no CD11c
Production
TNF
interferon 1/3
INF-a
IL-6
granzyme B
lymphoid primed multi‐potent progenitor (LMPP)
granulocyte–macrophage DC progenitor (GMDP)
macrophage DC progenitor (MDP)
common DC progenitor (CDP)
Plasmacytoid DC
Convential myeloid (cDC2)
Functions
Promote Th2 , Th1, Th17 and Treg
respond to intracellular pathogens, parasites, allergens, extracellular bacteria and fungi
TLR4, TLR5, TLR6, TLR2
Produce
IL12
IL10
IL23
TNF-a
Receptor
CD5
lymphoid primed multi‐potent progenitor (LMPP)
granulocyte–macrophage DC progenitor (GMDP)
macrophage DC progenitor (MDP)
common DC progenitor (CDP)
pre‐DC
cDC2 cell
Markers
CLEC10A
VEGFA
FCGR2A
Lack of cDC1 markers
Convential myeloid (cDC1)
Functions
Respons to intracellular pathogens
Natural killer responses through IL-12
Promote Th1 through IL-12
Cross-present via MHC class 1
to activate CD8+ T cells
to activate NK cells
Produce
type 3 interferon
IL12
CXCL9/10
lymphoid primed multi‐potent progenitor (LMPP)
granulocyte–macrophage DC progenitor (GMDP)
macrophage DC progenitor (MDP)
common DC progenitor (CDP)
pre-DC
cDC1
Morphology
CLEC9A key marker
CD33
CD141
CD13
CD11clow
CD11blow
Differentiation pathway
Differentiation pathway
Differentiation pathway