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Metabolic Syndrome - Coggle Diagram
Metabolic Syndrome
Characterized by
Inpaired glucose tolerance
Hyperinsulinemia and insulin resistance
Obesity
Hyperlipidemia or dyslipidemia
Hypertension
Excess nutrients
Reduced physical activity
Causes
Obesity
Alcoholism
Sedentary lifestyle
PCOS
hypercortisolism ex: steroid use or Cushing syndrome
Drugs ex: riframpicin, isoniazid,
Progesterone derivatives,
Antiretrovirals
Genetic causes ex: mutation
Dyslipidemia is
characterized by
Increased TAG pool in the body
Hypertriglyceridemia
Decreased HDL
Atherogenic small dense LDL predominates
Low HDL predisposes yo oxidation of LDL
People with MetS are
at increased risk of
Increased risk of coronary heart disease
Type 2 diabetes
PCOD
Non alcoholic fatty liver disease (NAFLD) that progresses to non alcoholic steatohepatitis (NASH)
Effects of insulin
resistance are
Stored TAG hydrolyzed - elevate FFA in plasma
Reduction of glucose uptake and utilization by muscle cells
Reduction of glycogenesis in liver
Decreased glucose storage in liver cella
Other names
Insulin resistance syndrome
Syndrome X
Cardiometabolic Syndrome
Laboratory
tests
Fasting insulin level > 160 pmol/L is positive evidence of insulin resistance