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CD4+ T-cells (TCR-MHII) - Coggle Diagram
CD4+ T-cells (TCR-MHII)
Th1
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effector molecules produced by Th1 cell after activation: IL-2, IFN-y, TNFy, GMZ
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Th2
effector molecules: IL-4 and IL-5, IL13, IL10,TGFb
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function: antibody and cellular respons to parasites (eosinophils, basophils, mast cells, support B-cells)
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cell surface marker: CCR4, CRTH2, CCR8,CD294
Th9
function: defense against extra-cellular parasites, mucosal autoimmunity, allergic reaction,and cancer regulation
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cell surface marker: CCR6, CCR3, CXCR3, but No distinctive marker
transcriptional factor: PU.1, STAT6
cytokines to differentiate into Th9: IL-2, IL-4, TGF-b
Th17
function: neutrophils activation, extracellar pathogen protection, epithelium activation in gut/skin
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effector: IL-17, IL-21, IL-22
cytokines for differentiation into th17: IL-6, IL-21, TGFb, IL-23
cell surface marker: CCR6, KLRB1
Tfh
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effector molecules: IL-21, IL4
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cytokines to differentiate into Tfh: IL-6, IL23, TGFb
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Treg
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effector molecules: TGFb, IL-10, IL35
cell surface marker: IL2, PD1, CTL4
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