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Pancreatitis - Coggle Diagram

- - - - Increase Protein Concentration in Pancreatic Secretions --> Promote Ductal Plugs
    - - Direct Toxic Effect on Acinar Cells --> Lipid Accumulation, Acinar Cell Loss & Parenchymal Fibrosis
    - - Generate Free Radicals in Acinar Cells --> Membrane Damage & Recruitment of Inflammatory Cells by Action of Chemokines
      - Promote Fusion of Lysosomes & Zymogen Granules --> Acinar Cell Necrosis, Inflammation & Fibrosis
  - - - Hard Gland, Dilated Ducts, Containing Calcified Secretions
    - - Chronic Inflammatory Infiltration
      - Atrophied/Hyperplastic Ductal Epithelium
      - Acinar Loss
      - Ductal Dilatation & Intraluminal Protein Plugs + Calcification
  - - - UFEME
      - FBC
      - CRP
      - Blood Glucose
      - Liver Function Test
      - Faecal Elastase Level (Low)
    - - CT-Scan
      - Endoscopic Ultrasound (EUS)