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Blood Pressure, HYPERTENSION BODY REGULATION - Coggle Diagram

- - - - BV ↑ → EDV ↑→ SV ↑
    - - SNS (+) by EPI and NE
        Hormon Tiroxin T3 T4 (+)
        Ion Ca2+ (+)
    - - = resistance to overcome to pump into arteries
      - HTN, atherosclerosis plaques, TPR
- - - - ESO angiodema, hiperkalemima, & dry cough => Not for asma & COPD
  - - - Good in CAD, HF, AF
      - Avoid in Asma/COPD, bradikardia, decompensate HF, hypoglycemia
        
        Asma? Pake yg BB kardioselektif
        (Block Beta 1 aja = BISOPROLOL)
    - - Avoid in hyperkalemia, CKD
      - Good in CAD, HF
  - - - ACEI ARB (teatogenik)
        Thiazide (lower BV) - placenta perfussion
    - - Hydralazine (direct vasodilator)
        Methyldopa (alfa 2 agonist)
        Labetalol (alfa and beta blocker)
        Nifedipine (CCB)
  - - - Kerja di TK proksimal, Loop, TK distal
        Utk HTN dan UDEM
      - !!ESO HIPOKALEMIA!!
    - - SPIRONOLACTONE
      - iv Manitol (osmosis agent)
        urgency only
        
        reduce tekanan ntrakranial dan intraokular
- - - - Cardiac Accelatory Centre
        SNS
        
        HEART
        
        SA Node, AV Node, Heart Muscle Contractility
        → HR ↑ and SV ↑
        
        ADRENAL MEDULLA
        
        EPI 80%, NE 20%
        
        alfa 1 - adrenergic R
        = Sympathetic R
        
        Vasoconstriction
      - Vasomotor Centre
        SNS
        
        NE
      - Cardiac Inhibitory Centre
        PSNS
        vagus nerve
        
        HEART
        
        SA Node, AV Node
        
        AcetylCholine
        to conduction syst cell
        
        muscarinic 2 - R
        w/ G inhibitory
        
        Blocks Cl- to cell
        Knock out K+ from cell
        
        Sel - - - - - -
        "Hyperpolarization"
        
        1 more item...
      - CA and VM center = down-regulate
        CI centre = up-regulate
- - - - Angiotensin I
        AT I
  - - - AT II
        
        ADRENAL CORTEX
        
        Aldosterone
        
        KIDNEY
        TK Distal
        
        Reabsorp Na+ water
        Keluarkan K+
        
        HYPOTHELAMUS
        GLAND
        
        ADH
        
        KIDNEY
        Tubulus Collectivus
        
        Reabsorp water
        
        BV ↑
        
        1 more item...
        
        THIRST
        
        AT II - R at
        BLOOD VESSEL,
        block bradykinin
        
        Vasoconstriction → BP ↑
        
        KIDNEY
        TK Proksimal
        
        Reabsorp Na+ Cl- water → BV↑
        
        EDV ↑→ SV ↑ → BP ↑
        
        AT II ACTIVITY INHIBITED
        by ANP
        (atrial natriuretic peptide)