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Thyroid Neoplasia - Coggle Diagram

- - - - Solitary
      - Well-Encapsulated Lesion
      - Most Are Non-Functional/Non-Secreting
  - - - Papillary (75-80%)
        
        RET/PTC, BRAF
        
        Most Common
        
        Female > Male (3:1)
        
        All Age (More in Advanced Age)
        
        Common Regional LN Spread, Rare Distal Metastasis
        
        Gross
        
        Enlarged Thyroid
        
        Single Nodule
        
        Painless
        
        Calcification/Bone
        
        Cystic Changes
        
        Microscopy
        
        Papillary Structures
        
        Orphan Annie's Eyes
        
        Psammoma Bodies
        
        Typical Clear Nuclei
        
        Folded Nuclear Membrane (Coffee Bean)
        
        Excellent Prognosis
      - Follicular (10-20%)
        
        RAS, PTEN
        
        Gross
        
        Encapsulated
        
        Necrotic & Hemorrhagic
        
        Microscopic
        
        Microfollicles
        
        Hurtle Cell Change
        
        Vascular Invasion
        
        Less Well Prognosis Than Papillary
      - Anaplastic/Undifferentiated (5%)
        
        RAS
    - - Medullary (5%)
        
        Familial Occurence (MEN)
        
        Calcitonin & Other Peptides Secretion
        
        Amyloid Stroma
        
        Gross
        
        Microscopic