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General Principles of Pharmacology - Coggle Diagram
General Principles of Pharmacology
I. Definition and scope of pharmacology
II. Movement of drugs to and from sites of action
A. Physicochemical factors in transfer of drugs across membranes
B. Weak electrolytes and influence of pH
C. Absorption of drugs
D. Distribution of drugs
III. Biotransformation of drugs
A. Consequences of metabolism
B. Biotransformation reactions
C. Metabolizing systems in the smooth endoplasmic reticulum ("microsomal" fraction of cell homogenates)
D. Non-microsomal biotransformation
IV. Excretion of drugs
V. Clinical pharmacokinetics
A. Introduction
B. Pharmacokinetic parameters
C. A simple pharmacokinetic model
D. A "dose-dependent" pharmacokinetic model
E. Intermittent oral dosing
F. Pharmacokinetics of single doses
G. Recapitulation of equations