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Macrocytic Anaemia - Coggle Diagram
Macrocytic Anaemia
Non-megaloblastic Macrocytic Anaemia
DNA synthesis not impaired
Macrocytic circulating RBC's
Round
MCV usually
< 110 fL
Mild anaemia
Exclude B12/folate deficiency
Liver Disease
Contributing factors to anaemia
Blood loss
Iron/folate deficiency
Suppression of haemopoiesis by alcohol
Lab features
MCV 100 - 110 fL
Codocytes
WBCs, platelets normal
Coagulation abnormalities - FII, FVII, FIX, FX
Reticulocytosis
Stimulated erythropoiesis
Causes
Blood loss
Destruction of RBCs
Lab features
Variable MCV
Anisocytosis (increased RDW)
Polychromasia
NRBCs
Megaloblastic Macrocytic Anaemia
Clinical Features
Folate Deficiency
More rapid onset
Excess demand or poor diet
Vit B12 Deficiency
Slow onset
GIT problems
Intrinsic factor
Development
Decrease in vitamin levels
Hypersegmentation
of neutrophils in peripheral blood
Oval macrocytes
in peripheral blood
Megaloblastosis in BM
Anaemia
Pernicious Anaemia
Absence of Intrinsic Factor (IF)
Diagnosis
ELISA
Gastric analysis (Schilling Test)