Please enable JavaScript.

Coggle requires JavaScript to display documents.

Iron Deficiency - Coggle Diagram

- - - - Microcytic hypochromic
      - Anisocytosis
      - Poikilocytosis
        
        Codocytes
        
        Elliptocytes
      - WBCs & platelets - normal
  - - - Pregnancy
      - Rapid growth in infancy & adolescence
      - Menstruation
    - - Medications
      - Malabsorption e.g. coeliac disease
      - Inherited e.g., mutations in iron regulatory proteins (matriptase 2 protein)
      - Loss of gastric activity e.g., aging, gastrectomy
    - - Haemorrhage
      - Haemolysis
  - - - ferrous sulfate (oral supplement)
      - Without food + Vit C (aid absorption)
- - - - Unavailability of iron e.g. Fe decrease, sideroblastic anaemia
      - Defective iron re-utilisation e.g. (ACD)
  - - - Ferritin
      - Haemosiderin
    - - Dependent on
        
        Condition of mucosal cells in GI tract
        
        Intraluminal factors
        
        Tissue iron stores
        
        Haematopoietic activity of bone marrow
    - - Transferrin
        
        Plasma transport protein (2 binding sites for ferric iron)
        
        Delivers iron to marrow for heme synthesis (incorporation into erythroblast)
        
        High expression of transferrin receptors on Fe requiring cells
        
        After releasing Fe to the cell transferrin and transferrin receptor are recycled
        
        Lab measures
        
        % Transferrin saturation
        
        Total iron binding capacity (TIBC)
        
        Ability of transferrin to bind iron