Please enable JavaScript.
Coggle requires JavaScript to display documents.
Introduction to Immunology (1.18.3.10) - Coggle Diagram
Introduction to Immunology (1.18.3.10)
Characteristics of Innate immunity
fast (hours/days)
short duration
no antigen recognition (non-specific)
broad range of receptor on a wide range of cells
can have regulation
no amplification
not self - discriminatory
no memory
Characteristics of adaptive immunity
slow response (days/weeks)
long duration
highly specific to antigens
highly specific receptors
T Cell receptors
B Cell receptor
lots of regulation
lots of amplification due to lots of proliferation
very self - discriminatory
lots of memory cells
link between innate and adaptive
cytokines
complement
antigen presenting cells
leukocyte characteristics
neutrophil
short lived
circulates in blood
migratory
follow chemokine gradients
phagocytic
lots of variability/species variation
monoctyes/macrophages
phagocytic
migratory/circulate in blood
can act as antigen presenting cells
innate and adaptive
lysosomal enzymes
macrophage once in tissue
eosinophils
circulate in blood
protective role against parasites
can look orange - dependant on stains
basophils
circulatei n blood
least common in normal blood
response to allergens
release histamine
mast cells
response to allergens
separate to basophils
within tissues
role in inflammation
natural killer cells
large granular
cytotoxic
destruction of infected virus cells
lymhocyte
dendritic cells
specialised group of APCs
can be in the gut
subsets according to tissue location
specific names
looking for benign/pathogens
long dendrites
b lymphocytes
express membrane bound receptors
central role in adaptive immunity
can differentiate
memory cells
plasma cells
t lymphocytes
cell mediated adaptive
recognise MHC
range of subsets
T Helper
Ctyotoxic T
leukoctyes
innate
neutrophil
eosinophil
basophil
natural killer cells
mast cells
adaptive
lymphocytes
b cells
t cells
memory cells
plasma cells
antigen presenting cells
monocytes
macrophages
b lymphocytes
dentdritic cels
MHCs
MHC Class 1
expressed on most cells
blood cells
MHC Class 2
primarily on APCs
macrophages
dendritic cells
b cells
glycoproteins expressed on cells surface that present peptide chains to other cells