Please enable JavaScript.
Coggle requires JavaScript to display documents.
Revisiting Inflammation (1.18.1.10) - Coggle Diagram
Revisiting Inflammation (1.18.1.10)
inflammation
protective response again infection/injury
typical signs
redness
swelling
pain
can occur in any organ
most common in the skin and underlying tissues
triggers
nick your skin
bitten
toxin
invasion by antigens
acute inflammation
tissue resident immune cells encounter an inflammatory stimulus
toxin
pathogen
injured host cell
binding of the the stimulus to the receptor triggers a cascade
activates the production of cytokines
inflammatory chemicals dilate blood vessels
vasodilation accounts for heat and swelling
complement proteins
promote phagosytosis
three phases of infiltration of blood components into tissues
infiltration of plasma fluid
antimicrobial mediators
clotting factors
plasma fluid
infiltration of neutrophils
phagocytes that destroy
adhesion of neutrophils to blood vessel membrane
chemical cues guide the neutrophils to the stiulus
monocytes
monocytes differentiate into macrophages
macrophages remove pathogens
macrophages are cleared by the lymphatic system
signals
released when cells are damaged
prostaglandins
histamines
cytokines
cause vasodilation
results in heat and redness
heat makes the environment unbearable for some stimuli
attract specific types of cells
more white blood cells
swelling (oedema)
attracts neutrophils and monoctyes
phagocytosis
removal or bacteria and debris
chronic inflammation
when acute inflammation doesnt go away after the stmulus is removed
harmful
deals damage to healthy tissues
chronic condition precursor
asthma
cancer
cardiovascular disease
diabeted
arthritis