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Dev. Système Nerveux - Coggle Diagram

- - - - composed by bi-polar c.in a neural filet
      - 6000 c. control spontaneous contractions
        
        response to mechanical + photo stims
        
        response to complex alimentation + locomotion
  - - - stereotypical: easy to follow lineage + growth of each c.
        
        P germinal cells grow inside embryo (MS, C, D, E)
        
        AB cells produce cells that grow outside of embryo
      - simple structure:
        
        959 cellules au total
        
        302 neurones + 56 glia organized by in cords + nerves
      - rapid generation time: 2 days
        
        efficient sniping mutant c.
      - highly reproducible
      - (MEMORIZE SLIDE 25 CHART)
        
        MS/C/D/E prolif inward, AB outward
        
        Prolif phase into layers + indentation
        
        Start of morphogenesis via indentation -> ecto/meso/endoderm
        
        AB deriv on VENTRAL side divide to produce neurons
        
        migr. towards interior of embryo to make NS
        
        Senso neurons
        
        Motor neurons
        
        Ganglions of central ring
        
        +++rings = commissures (surrounding somatic muscl)
        
        Neuronal c. bodies near head = ganglia
  - - - rapid gen time (8.5d)
      - +++#eggs & small size
      - Low $$$ high-intensity screening ("criblage haut-débit")
      - genetic traceability:
        
        14000 genes 4 chromosomes
      - highly conserved genome + biology via evolution
    - - Fertilized egg
      - Early cleavage
        
        Nuclear divisions happen 1st
        
        Forms SYNCTITIUM center of egg = Acellular Blastoderm
      - 3.4. Synctital blastoderm
        
        nuclei migrate towards exterior -> plasma membranes form cellularisation
        
        Form blastoderm
      - Cellularisation
      - Gastrulation
        
        Ventral region of blastoderm gastrulates -> mesoderm -> 3 layers
      - Neuroblasts ectoderm VENTRAL AREA -> progenitor c. (mother ganglion c. = GMC)
        
        GMC -> prod. 2neurons/glia = corde nerf ventrale
  - - - external layer of embryo = ECTOderm's VENTRAL region
  - - - blastomeres split towards bottom of embryo = EPIBOLE (epibody)
- - - - Studying simpler organisms help understand basic principles
  - - - prolif. fecunded cell to create a sphere of c. = BLASTULA
    - - Reorg. of c. blastula = endo/meso/ectoderm layers
    - - NERVOUS SYSTEM