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Multiple Mieloma, image, image, image - Coggle Diagram
Multiple Mieloma
Neoplastic proliferation
of malignant plasma
cells in Bone Marrow
Bone Marrow
Hipercellularity
Hiperproduction of Abnormal
Immunoglobulines
called "M proteins"/
"Monoclonal proteins"
M spike on SPEP
Most common due to
monoclonal IgG
followed by IgA
Production of the exactly the same antibody
Lacks Antigenic Diversity
More risk of infections
(Infection is the most common cause of death)
Decreases charge
between RBCs
Rouleoux formation
on blood smear
Protein M has only 1
LIGHT CHAIN
FREE light chain
circulates in serum
Deposits in Tissues
Primary AL Amyloidosis
Deposition in kidney tubules
(Myeloma kidney-renal failure)
Excreted in urine
"Bence-Jones proteins"
Cells produce Osteoclastic activator factor
Activate RANK Factor
Ca+ reabsorption
Hypercalcemia
Increased risk of fracture
Lytic "punched-out"
(Skull and vertebrae)
Bone Pain
This malignant cells
produces IL-6
Grow factor for malignant cells
(T/B Cells growth)
