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Problems with blood cells - Coggle Diagram
Problems with blood cells
Anemias
<13.5/<12.5 M/W
Size based classifications
Microcyttic (<80)
Iron/HGB deficiency
Types
IDA (most common at 80%)
ACD
Thalassemia
Sideroblastic
Macrocytic (>100)
B12 deficiency
Prenicious anemia (autoimmune destruction of IF)
Folatae deficiency
Normocytic (80 - 100)
exxtravascular hemolysis
Hereditary spherocytosis
Intravascular hemolysis
Sick cell disease
Leukemias
coagulopathies
Disorders of primary hemostasis
Haemophilia
A
F8 (most common)
B
F9
C
Jews
Disorders of secondary hemostasis
Disorders of thrombolysis
normal physiology
serum components
Erythrocytes
reticulocyte precursor
Normal mass = >13.5 for men and 12.5 for women
Measures
HCT
HGB
RBC count
Reticulocyte count
TIBC
Ferratin
Transferrin
Leukocytes and lymphocytes
Lymphocytes
B cells
Bone marrow maturation --> B cells --> LNs
T cells
Thymus maturation (+/- selection) --> LN
CD4+
CD8+
Leukocytes
Granulation cells
macrophages/monocytes
Platelets
hemostasis
Primary
formation of platelet plug
Adhesion
VWF + GP1
Activation
Alpha
Fibrin(ogen?)
TXAII
Deep
Ca2+
ADP
Conformational change
Aggregation
GPIIb/IIIa
Secondary
Formation of fibrin clot
Mediated by clotting cascade
Extrinsic: 3 + 7
Intrinsic: 12, 11, 8, 9
Common: 1, 2, 3, 10, 13
Clot resorption (thrombolysis)
ThrombinA2???
APC complex, protein S, protein C (?) mediated