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One-ended DSB - Coggle Diagram
One-ended DSB
Repair
53BP1 early pathway
How 53BP1 repair?
Interaction?
Rad18
RHINO?
Direct interaction
Direct intereation
53BP1 dependency?
ATR dependecy?
ATM dependency?
9-1-1?
Interaction?
POLQ?
BRCA2 late pathway
Repair Defet
Nuclear Fragmentation in BRCA2-
53BP1
DSB mobility?
POLQ
Repair in mitosis?
Lamin A
DSB mobility?
DSB mobility up during mitosis via 53BP1 and Lamin interaction?
N-ter Phos regulates 53BP1 and Lamin interaction?
Fragmented Nuclearでの
ラミン形成異常
cGAS/STING?
Inflammation?