The Isthmus of Panama has served as a bridge for cultures from the North, South, and the Caribbean since its geological formation, facilitating cultural exchange.

The settlement of the Isthmus occurred in several stages, beginning between 11,000 and 10,000 B.C., known as Panama's Prehistory.

Various indigenous cultures inhabited the region, leaving archaeological legacies such as the Coclé Culture and the Darien Culture.

Christopher Columbus arrived on Panama's coasts during his fourth voyage in 1502, exploring the territory and making contact with the indigenous people.

The Spanish implemented the Laws of Burgos to regulate the treatment of the indigenous population, but encomiendas and mistreatment of indigenous people persisted.

The depopulation of coastal areas due to the exploitation of indigenous people in gold and pearl mines led to the extinction of entire communities.

During the colonial era, Panama became an important commercial and transit center between Spain and its American colonies.

The construction of the Camino Real, a land route crossing the Isthmus, facilitated the transportation of goods and treasures between the Atlantic and the Pacific.

Panama City became a strategic port and center for trade, enriching the Spanish Crown.

After gaining independence from Spain in 1821, Panama joined Gran Colombia, a republic comprising Venezuela, Colombia, Ecuador, and Panama.

In 1855, Panama became a Federal State with a degree of autonomy, moving towards its future independence.

On November 3, 1903, Panama declared independence from Colombia with the support of the United States, marking the beginning of the Republic of Panama.

The construction of the Panama Canal began in 1904, a project that would revolutionize global economy and trade by facilitating ocean-to-ocean passage.

Throughout the 20th century, Panama experienced economic growth and rapid modernization, with developments in infrastructure and services.

Panama's population continued to diversify with the arrival of immigrants from different countries, enriching the country's culture and society.

Panama solidified its position as a significant financial and business hub in Latin America.

The country faced political and social challenges but also achieved progress in education, healthcare, and quality of life for its population.