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Systemic Lupus Erythematosus - Coggle Diagram
Systemic Lupus Erythematosus
Multifactorial pathogenesis
Etiology not fully known
Genetic
HLA
Hormonal
Estrogen
Environmental Factors
Viruses (EBV)
Leads to
Acquired sensitivity to auto-antigens
Cytotoxic T lymphocytes
Promotes inflammation
B lymphocytes
Develop autoantibodies
Immune complex formation
Loss of tolerance
Altered apoptosis doesn't remove cells that recognize "self"
Manifestations
Skin rashes
Malar (butterfly rash)
Discoid
Kidneys
Glomerulonephritis
Proteinuria
Musculoskeletal
Joint pain
Joint swelling
Effusions
Pericardial
Pleural
Neurologic
Seizures
Psychosis
11 Criteria for Classification
Rash
Ulcers
Arthritis
Pleuritis
Proteinuria
Neurologic involvement
Hematologic involvement
Lab values
Anti-DNA Antibody
Anti-Sm
Syphilis false positive
Abnormal antinuclear antibody (ANA)
Treatment
Determined by
Manifestations
Side effect tolerance
Pharmacotherapy
Anti-inflammatory
Immunosuppression
Adverse Effects
Osteoporosis
Hypertension
Diabetes
Infection due to immunosuppresion
Atherosclerotic heart disease
4 out of 11 needed to diagnose