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Systemic Lupus Erythematosus (SLE) - Coggle Diagram
Systemic Lupus Erythematosus (SLE)
Clinical Manifestations
organs mostly affected: skin, kidney, musculoskeletal system
joint pain
skin rashes
fatigue
pericardial effusion
pleural effusion
pathogenesis
potential etiologic factors
viruses (EBV)
hormones (estrogen)
genetic predisposition (HLA)
drugs (e.g.,procainamide)
loss of tolerance
acquired sensitivity to auto-antigens
autotreactive CD4+ T cells
polyclonal C cell hyerreactivity
autoantibody production
immune complex formation in circulation and tissues
tissue injury
gloerulonephritis
vasculitis
serositis
arthritis
treatment
initially
Anti-infammatory
salicylates
NSAIDS
Glucocorticoids
Aggressive cases
Immunosuppression
Hydoxychloroquine
Azathioprine
Cyclophosphamide
Methotrexate
DMARD
delay progress
MHC and HLA
unknown event
stimulation of APC
activation of B lymphocytes
permanent organ damage
evasion of normal immune response
apoptosis
alteration of antigens