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Systemic Lupus Erythematosus - Coggle Diagram
Systemic Lupus Erythematosus
What is it?
Type 3 Hypersensitivity Reaction
Autoimmune Disease
Innate and humoral immune system
Persistent Antigen-promoting complex deposition and inflammation
Antigens present in all cells
Potentially damage a wide range of cell types and location
Pathophysiology
Not fully known
Genetic or familial tendency
combine with hormonal and environmental influences
Women, disease flare-ups, infection or another pathologic process
Altered removal of cells that recognizes "self" by apoptosis is altered
B Lymphocytes to develop autoantibodies and cytotoxic T Lymphocytes
Promote inflammation and complex deposition in susceptible organs of the body
Can cause permanent brain damage
Clinical Manifestation
Organs commonly Affected
Skin, Kidney, Musculoskeletal System
May develop Neurologic, Pulm, Cardiac Disease
Joint Pain, Swelling, Skin Rashes, Fatigue, Pericardial Effusion, Pleural Effusion
Diagnostic Criteria
Determined by combination of subject, symptoms, objective physical findings, lab values
11 Criteria, 4 must be presented to obtain diagnosis
Rash
Butterfly and photosensitivity
Ulcers
Mouth and Nasopharynx
Proteinuria
Arthritis
in at least 2 peripheral joints
Pleuritis or pericarditis
Seizures or Psychosis
Neurologic Involvement
Anemia, Leukopenia, Thrombocytopenia
Hematologic Involvement
LAB Values and Anti-DNA antibody, Anti-Sm, or a False-positive test for syphilis
Abnormal Antinuclear Antibody
Treatment
Varies Among Individual
Early Treatment
decrease morbidity and mortality
Pharmacologic Management
NSAIDS
Cortocosteriods
Symptom Control and anti-inflammatory reaction of mother and child
Anti-rheumatoid Drugs
Can delay the progress and resulting damage
Antimalarial Drug Plaque-nil
May slow disease Progress
Aggressive Care
Immunosuppressant Drugs