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CANCER AND THE CELL CYCLE - Coggle Diagram
CANCER AND THE CELL CYCLE
TUMOR SUPPRESSOR GENE
segments of DNA
negative regulator proteins
prevent the cell from undergoing uncontrolled division.
activated
code
EXAMPLE
gene Rb, p53, and p21,
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PROTO-ONCOGENE
code for the
positive cell-cycle regulators
normal gene
mutated
oncogene (cancerous gene)
oncogene
in the cell cycle
alteration of the DNA sequence
non-functional protein.
prevent the cell from completing the cell cycle;
cell cannot reproduce
mutation is not propagated
damage is minimal
gene mutation
increase activity of
posstive regulator
EXAMPLE
Mutation
Cdk gene
activated without cyclin
cell pass a checkpoint before all of the required conditions
cells are damaged
can not
further cell divisions
no muataion and no harm to the organism
can
further cell division
daughter cells can acumulate
more mutation