Can and could all humans live to 100 or beyond? (What factors affect longevity?)

Genetics

“25 % of the variation in human longevity is due to genetic factors” - (Passarino, G. et. al. 2016)

Biologically

Gender

Socially

preterm births and the neonatal and infant mortality rates higher in boys

Genetic disorders more common in males

female sex hormone oestrogen protective of cardiovascular diseases (CVD) / partly responsible for the lower incidence of CVD in women until menopause vs. androgen hormone (higher in men) associated with a higher risk of CVD

Female bodies are known to produce stronger immune responses and larger amounts of antibodies compared with male bodies - better at fighting off infections & diseases

Misogyny and stereotypes shortens male longevity

Men are more exposed to work-related stress and unhealthy behaviours (e.g. smoking & alcohol abuse)

More men are disadvantaged by occupational hazards and “masculine behaviours” that are highly risky and health hazardous -> die in work-related accidents, car crashes, war and sporting activities

Testosterone “responsible for predisposing men to health risk behaviours”

maybe why research has found a link between marriage and increased life expectancy in men but not in women

Marriage may protect men from risky social habits, whereas women are less prone to risky behaviours regardless of their marital status (see Wellbeing / mental health section)

Compared with the past, the gender gap in life expectancy has reportedly narrowed in most low-mortality countries in the last few decades

not surprising given that women have been increasingly entering the workforce and adopting health-damaging lifestyles like smoking and drinking

male foetus is biologically weaker and more vulnerable to maternal stress and pregnancy complications than the female foetus

Chronic health conditions that shorten life

Lifestyle choices / health (not everyone able to make these choices - see Socioeconomic status section)

Cardiovascular health (CVH)

What does it include?

Blood pressure

Total cholesterol level

Triglyceride level

Heart rate recovery (how long it takes your heart to return to resting after exercise) - the quicker the better

How to improve CVH

Exercise

Lose weight

Good diet

Don't smoke

Reduce stress

How does it affect longevity?

Better CVH live longer -> reduces risk of CV diseases such as heart attacks etc. which can be fatal

"Participants with high CVH had an average 8.9 more years of life expectancy at age 50 years compared with those with low CVH. On average, 42.6% of the gained life expectancy at age 50 years from adhering to high CVH was attributable to reduced cardiovascular disease death. ” (Hao Ma et. al., 10 April 2023)

Hygiene

Disease prevention

Washing hands before eating etc

Chronic pain

e.g. Oral hygiene

gum disease, such as periodontitis, can lead to heart disease. This is due to the bacterial buildup in the mouth which can cause an infection in the bloodstream and then make its way to the heart

Parasites

E.g. STDs

Self-esteem / mental health

a better self-esteem actually promotes the production and the absorption of serotonin which can help to better their mental health (see Wellbeing / health section)

Diet & Nutrition

Affects CVH (see section) E.g. eating an excess of fat, salt or sugar can increase risk of heart disease

Everything in moderation (E.g. sugars are an important part of nutrition however too much can cause diabetes)

Fresh foods are better than processed ones as they often contain healthier ingredients

Different diets for different cultures (see Culture / Ethnicity section)

Substance abuse

Tobacco

Why does it kill?

“There are some 1.1 billion people who smoke on our planet earth. Just less than one-third of all adults in the world smoke regularly. Tobacco deaths will not only occur in old age but will start when smokers are about age 35. Half of those who die from smoking-related causes will die in middle age, each losing about 25 years of life expectancy. More than 95% of the tobacco consumed is in the form of cigarettes. About half of all smokers who undergo lung cancer take up smoking again.” (Dying to Quit," a 1998 book by Janet Brigham)

Causes lung cancer & CVD

Alcohol

Negative effects

Those drinking 14 to 25 drinks per week could expect a shorter life expectancy by one to two years

Those drinking more than 25 drinks per week could expect a shorter life expectancy by four to five years

Is drinking some alcohol better than not drinking it at all?

“Light drinkers (those consuming one to three drinks per week) had the lowest rates of cancer or death compared to those drinking less than 1 drink per week” (Kunzmann, Andrew T. et. al., 2018)

Why does it kill?

Drink driving / drawing / alcohol poisoning (short term)

High blood pressure, heart disease, stroke, liver disease, and digestive problems. Cancer of the breast, mouth, throat, esophagus, voice box, liver, colon, and rectum (long term)

Risky lifestyle / bad choices

Obesity

Every situation is different

“more likely than non-overweight children to develop diabetes and cardiovascular diseases at a younger age, which in turn are associated with a higher chance of premature death and disability”

increased risk of so many medical complications

moderate obesity, which is now common, reduces life expectancy by about 3 years, and that severe obesity, which is still uncommon, can shorten a person’s life by 10 years

Sleep

Good for overall health

Affects blood sugar

Reduces stress levels

Decrease inflammation

Maintain healthy body weight

Increase energy and alertness

Improve memory

Improve executive function

Repairs tissue

Strengthens heart

Improve overall health -> improve longevity (see Wellbeing / health section)

“Research suggests that regularly sleeping for less than seven hours a night can have negative effects on the cardiovascular, endocrine, immune, and nervous systems. Side effects of sleep deprivation can include obesity, diabetes, heart disease, hypertension, anxiety, depression, alcohol abuse, stroke, and increased risk of developing some types of cancer.” (Stibich, M. 2021)

Wellbeing / mental health

Culture / ethnicity

Japanese women & men currently live 5-6 yrs longer than Americans” Japan has

Diet

In recent years, diets in Japan have become more similar to those in the U.S. but they still eat smaller portions, more fermented foods, less sweets, and less red meat

Culture encourage better lifestyle habits / culture that reveres elders so they have better mental health, less loneliness, and better healthcare

Less obesity “prevalence of obesity among U.S. women is about 37% but among Japanese women is less than 5%

Chronic stress can shorten lifespan

Excessive cortisol levels cause heart disease, heart attack, high blood pressure and stroke; Sleep problems; Weight gain; Memory and concentration impairment
exacerbate physical health problems, such as increased risk for heart attack or diabetes

Marriage / commited relationships

(improve cardiac health, help combat isolation and loneliness that can negatively impact mental health, and partner can motivate people to make healthier choices like keeping regular doctor visits and giving up unhealthy habits

Socioeconomic status

Education = higher socioeconomic status

Higher socioeconomic status leads to longer lifespan

Better access to healthcare

Ability to manage factors such as stress, sleep, substance abuse, exercise, hygiene, diet/nutrition better

Less likely to engage in risky behaviours / substance abuse

Global

Clean, safe food and water

Freak accidents

Pandemics / epidemic

Climate change extreme weather events and reduced air quality

Advancements in healthcare and science

“in the last decades, the continuous extension of lifespan was mainly due to the improvement of medical assistance with respect to age-related diseases, especially Cardiovascular Diseases and Cancer, which allowed to increase lifespan of 5 years in the last 2 decades and of 2 years in the last 10 years" (data from www.mortality.org and www.istat.it).