Bacterial pathogenesis begins with the entry of bacteria into the host's body through various ways, including the respiratory tract, digestive tract, oral cavity, nails, and others. After that, the process of adhesion-colonization occurs. In this process the bacteria attach to the surface of the host cell, the attachment of the bacteria occurs to the epithelial cells. In this process, the attachment of bacteria to the host cell surface requires adhesin proteins. Adhesin is divided into two, namely fimbrial and afimbrial. Fimbrial adhesions act as ligands and bind to receptors present on the host cell surface. Fili are often known as colonization antigens because of their role as attachment tools to other cells