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CHOICE OF AN ANTIMICROBIAL AGENT, DISADVANTAGES OF ANTIMICROBIAL…
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FAILURE OF ANTIMICROBIAL THERAPY
Improper selection of drug, dose, route or duration
Noncompliance by the patient
Treatment began too late
Failure to take adjuvant measures
Impaired host defence
Infecting organism present behind barriers
Trying to treat untreatable (viral)infections or other causes of fever (malignancy, collagen diseases)
Presence of altered or dormant organisms - relapse