ANTIMICROBIAL DRUGS ANTIBIOTICS are substances produced by microorganisms, which selectively suppress the growth of or kill other microorganisms at very low concentrations
C. SPECTRUM OF ACTIVITY
B. TYPE OF ORGANISMS
D. TYPE OF ACTION
E. NATURAL SOURCES OF ANTIBIOTICS
A.CHEMICAL STRUCTURE
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1. ANTIBACTERIAL: Penicillins, Aminoglycosides, Erythromycin, Fluoroquinolones, etc.
2. ANTIFUNGAL: Griseofulvin, Amphotericin B, Ketoconazole, etc.
3. ANTIVIRAL: Acyclovir, Amantadine, Zidovudine, etc.
4. ANTIPROTOZOAL: Chloroquine, Pyrimethamine, Metronidazole, Diloxanide, etc.
5. ANTHELMINTIC: Mebendazole, Pyrantel, Niclosamide, Diethyl carbamazine, etc.
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NARROW-SPECTRUM Penicillin G Streptomycin Erythromycin
BROAD-SPECTRUM Tetracyclines Chloramphenicol
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PRIMARILY BACTERIOSTATIC Sulfonamides Tetracyclines Chloramphenicol Erythromycin Clindamycin Linezolid Ethambutol
PRIMARILY BACTERICIDAL Penicillins Cephalosporins Aminoglycosides Vancomycin Polypeptides Fluoroquinolones Cotrimoxazole Metronidazole Rifampin Isoniazid Pyrazinamide
BACTERIA Polymyxin B Tyrothricin Colistin Aztreonam Bacitracin
ACTINOMYCETES Aminoglycosides Macrolides Tetracyclines Polyenes Chloramphenicol
FUNGI Penicillin Griseofulvin Cephalosporin
CLASSIFICATION
F.MECHANISM OF ACTION
CAUSE LEAKAGE FROM CELL MEMBRANES Polymyxin, Colistin, Bacitracin,Amphotericin-B
INHIBIT DNA GYRASE Fluoroquinolones - Norfloxacin, Ciprofloxacin,etc.
CAUSE MISREADING OF mRNA → AFFECT PERMEABILITY Aminoglycosides - Streptomycin, Gentamicin, etc
INTERFERE WITH DNA FUNCTION Rifampicin
INHIBIT PROTEIN SYNTHESIS Tetracyclines Chloramphenicol Erythromycin Clindamycin Linezolid
INTERFERE WITH INTERMEDIARY METABOLISM Sulfonamides, Sulfones, Trimethoprim, Pyrimethamine, Paraaminosalicylic Acid (PAS), Metronidazole
INHIBIT CELL WALL SYNTHESIS Penicillins, Cephalosporins, Monobactams, Carbapenems, Vancomycin, Cycloserine, Bacitracin
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18. OTHERS: Rifampin, Spectinomycin, Sod. fusidate, Cycloserine, Viomycin, Ethambutol, Clofazimine, Griseofulvin
17. AZOLE DERIVATIVES: Miconazole, Clotrimazole, Ketoconazole, Fluconazole.
16. POLYENE ANTIBIOTICS: Nystatin, Amphotericin-B, Hamycin.
15. NICOTINIC ACID DERIVATIVES: Isoniazid, Pyrazinamide, Ethionamide.
14. NITROIMIDAZOLES: Metronidazole, Tinidazole, etc.
13. NITROFURAN DERIVATIVES: Nitrofurantoin, Furazolidone.
12. POLYPEPTIDE ANTIBIOTICS: Polymyxin, Colistin, Bacitracin, Tyrothricin.
11. OXAZOLIDINONE: Linezolid.
10. GLYCOPEPTIDE ANTIBIOTICS: Vancomycin, Teicoplanin.
9. LINCOSAMIDE ANTIBIOTICS: Lincomycin, Clindamycin.
8. MACROLIDE ANTIBIOTICS: Erythromycin, Clarithromycin, Azithromycin, etc.
7. AMINOGLYCOSIDES: Streptomycin, Gentamicin, Amikacin, Neomycin, etc.
6. NITROBENZENE DERIVATIVE: Chloramphenicol.
5. TETRACYCLINES: Oxytetracycline, Doxycycline, etc.
4. Β-LACTAM ANTIBIOTICS: Penicillins, Cephalosporins, Monobactams, Carbapenems.
3. QUINOLONES: Nalidixic acid, Norfloxacin, Ciprofloxacin,etc.
2. DIAMINOPYRIMIDINES: Trimethoprim, Pyrimethamine.
1. SULFONAMIDES AND RELATED DRUGS: Sulfadiazine and others, Sulfones—Dapsone (DDS), Paraaminosalicylic acid (PAS).