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cellular energetics - Coggle Diagram

- - - - types of inhibitor
        
        1 competitive: inhibitor and substrate competes for enz, only 1 can bind. Rxn can reach Vmax at higher km
        2 non-competitive: both inhibitor and substrate can bind, but inhibitor will block enz function. Rxn cannot reach Vmax, km remains the same
        3 un-competitive: have same affinity for free enz and enz-substrate complex. Rxn cannot reach Vmax, km decreases
        4 mixer: can bind both free enz and complex. some have higher affinity for free enz, other for enz-substrate complex. Rxn cannot reach Vmax, Km can increase or decrease depending on affinity
      - a special activator and cooperativity:
        Some substrate can act as an activator, binding can increase activity at other active sites
- - - - Reaction coupling: an exergonic rxn linked with an endergonic rxn. The link occurs through a shared intermediate.
        
        How does ATP drive different types of rxn through rxn coupling?
        In fist rxn, ATP hydrolysis produces an unstable phosphorylated shared intermediate, which makes the second rxn exergonic.
        1 Eg: synthesis of sucrose
        (1) glucose + ATP = glucose-6-phosphate + ADP + energy
        (2) glucose-6-phosphate + fructose = sucrose + Pi
        2 Eg: Na / K pump (Na /K ATPase)
        (1) when binding to Na
        ATP + ATPase = ADP + ATPase (phosphorylated and hence change conformation)
        (2) when binding to K
        ATPase (phosphorylated) = ATPase + Pi
  - - - Catabolic pathway: a series of linked rxns that break down a larger molecule into smaller ones, usu. releases ENG
    - - Anabolic pathway: a series of rxns that build a larger molecule from smaller ones, usu. requires eng.