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Teratology - Coggle Diagram

- - - - Autosomal dominant
      - Autosomal recessive
      - X linked disorders
- - - - Excessive enviro temp (e.g. sauna)
      - Pyrexia (fever) e.g. pyrogenic infections
  - - - Asphyxial foetal death
      - Cerebral/adrenal/renal/hepatic anoxia-ischaemia --> injury
      - Intra-uterine growth retardation (IUGR)
  - - - Thalidomide used as a sleeping pill during pregnancy
      - Linked with outbreak of congenital defects 1957 - 1962
- - - - Teratogens are highly effective/damaging --> often numerous malformations
    - - Period of rapid growth & maturation
- - - - Affect a specific cell population
      - Or act only during a specific developmental period
      - Involve only one or a few organ systems e.g. Hyperthermia
    - - Affect a variety of cell populations
      - Act during many stages of development
      - Involve several organ systems & wide variety of defects
      - E.g. Rubella virus, bovine viral diarrhoea virus (BVDV)