Please enable JavaScript.
Coggle requires JavaScript to display documents.
Antimicrobial Testing - Coggle Diagram
Antimicrobial Testing
Mechanisms behind antibiotic resistance
When an antibiotic has lost its ability to effectively control or kill bacterial growth
Bacteria are "resistant" and continue to multiply in presence of therapeutic levels of the antibiotic
Mode of action
Cell wall
Plasma membrane
Ribosomes
Metabolic pathways
DNA synthesis
RNA synthesis
Multiple classes of antibiotics
Mode of action
Bacteriostatic
Bactercidal
Spectrum of action
Broad
Narrow
Different methods of susceptibility testing
Dilution (broth)
Tube dilution
Broth microdilution
Diffusion (agar)
Disc diffusion
E-test
Concept of susceptibility breakpoints
Purpose
Advise on patient therapy
Breakpoints
S-Susceptible
High likelihood of therapeutic success using a standard dosing regimen of the agent
I-Susceptible, increased exposure
There is a high likelihood of therapeutic success because exposure to the agent is increased by adjusting the dosing regimen or by its concentration at the site of infection
R-Resistant
High likelihood of therapeutic failure even when there is increased exposure