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Eliquis (APIXAPAN) drugs called as novel drug - Coggle Diagram
Eliquis (APIXAPAN) drugs called as novel drug
is their mechanism of action
called novel drug
more convenient for patients and healthcare providers
2--- Eliquis prevents the formation of blood clots. and with minimal effect on hemostasis
used for stroke prevention in
non valvular atrial fibrillation and initial and Long-Term Treatment and Prevention venous thromboembolism.2019 Elsevier (phase two )
BMI of at least 40 kg/m2 to benefit from more convenient, and possibly safer, anticoagulants(.Margarita Kushnir 2019)
use safety with Chronic Kidney Disease as less bleeding ( Miho Kimachi -2019 )
used for the treatment or prevention of venous thromboembolism or embolic stroke in children
as they are available in oral formulations
do not require drug monitoring.
were either unfractionated heparin or the low-molecular-weight heparins and .need either intravenous access or daily subcutaneous injections, in addition to multiple venipunctures to monitor drug concentrations.
Direct oral anticoagulants provide an alternative, and potentially safer, choice for children, in children and infants with congenital and acquired heart disease
Apixaban for treatment of embolic stroke of undetermined source
insertable cardiac monitor and the effects of early anticoagulation
phase three
treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of DVT after hip or knee replacement surgery.
predictable anticoagulant effect
routine monitoring of blood levels is not required.
lower risk of drug interactions and less toxicity
do not require dietary restrictions.
Relative risk ratio
Drug delivery
enhance quality of life
show favorable cost-benefit
more safety tolerability
several advantages.
it is a direct oral anticoagulant (DOAC) inhibit a specific clotting factor called Xa
1-- very essential factor in the blood clotting cascade to be completed as prevent further formation of blood clot
Indirect
Direct
activation of pathway
Intrinsic
extrinsic tissue pathway
prevent blood clots
has a rapid onset of action and a relatively short- half life .