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CRISPER CAS 9 - Coggle Diagram
CRISPER CAS 9
limitation
time consuming
off target effect
changes to the germ line
research and responsibility
Not efficient
advantages
simple to amend target
drug research
drug research
ideal gene editing technology
curing genetic disease)
cancer treatment
non viral infection
viral infection
therapeutics
calloboration in support with developing medicine
beta thalassemia
various cancer types1
including sickle cell disease
diabetes
research purpose
commercialize medicine
cure disease
develop medicine
history of therapeutics
founded in 2013
founded by Emmanuelle charpentier
history
discovered from Escherichia coli bacteria
Dr. Emmanuella charpentier co invented CRISPER)
discribed inb1987 ishino et al from osaka university
commercial application
in humans
established genetically modified cell
potential efficacy have been observed
explore the function of cancer related gene
treatment of monogenic disease
treatment of infections diseases
non viral disease
viral disease
in animals
animals grow bigger and faster
knock out Dna in reserch mice and rats
modify the genome of complex animals
acute vascular rejection mechanism
to produce edited pigs to intend preventing huper acute rejection
in plants
more predictable
to make plant breeding faster
increasing crop improvement
crop yield
quality
stress resistence
produce parthinocorpic tomato
first use of crisper
plant gene editing in2013