CRISPER CAS 9
Histry
Advantage
click to edit
commercial application
.
click to edit
click to edit
click to edit
click to edit
From Escherichia coli bacteria
first discover in sequence of DNA
.
Therapeutics
described in 1987
cost effectiveness
high accuracy
simplicity
multiplexing
quickly create animals model
directly applied in embryo
damage DNA
Limitation
.
click to edit
click to edit
incomplete editing
inaccurate on target or off target editing
lack of on target efficiency
unwanted changes in human embryo
not always efficient
may initiate mutation
In animals
)
animals grows bigger and faster
produce edited pigs
potentially promote tolerance in pigs
manipulate the genome of organism
preventing hyper acute rejection
In plants
improve quality and nutrational value
click to edit
used in growing monocot and dicot plant species
defend against pest
enhance tolerance to biotic and abiotic stress
first use of crisper in plants in 2013
In human
T cell can reveal the gene regulatory network in primary cell
click to edit
inherited eye disease
such as inherited blood disorder
understanding complex regulatory network in TME
treated many human genetic disease
explore the function of cancer related gene
click to edit
discover and develop potential new treatment and genetic cause of human disease
click to edit
established partneeship with other compnies
research develop and commercialize medicine
having several drugs in development for blood disease:
used to ameliorate disease
allow Dna to specifically modified and edited
rare blood disorder