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BMET1960, CARDIOVASCULAR DISEASE, laser, specific wavelength of light -…

- - - - Laminar
      - Turbulent
      - Disturbed
    - - magnitude
      - distribution
- - - - Cell
        
        Engineered Tissue
        
        Hard (Bone)
        
        Soft( Skin, Liver, Cartilage, Brain)
        
        Polymer
        
        Gelatine
        
        Collagen
        
        Silk
        
        Hydrogels
        
        Biological derived materials
        
        native ECM molecules
  - - - therapeutics
        
        Targeted drug delivery
        
        Targeted cell killing
        
        No drug attached
        
        Doesn't kill self on it own
        
        Trigger non invasively
        
        Heat
        
        Photothermal Therapy (PTT)
        
        1 more item...
        
        Photodynamic Therapy (PDT)
        
        1 more item...
      - biosensing for diagnostic
        
        biological imaging
        
        some NP Fluoresce
        
        sensing of biomolecules
    - - In vivo
        
        Culture the cells in the presence of NP
        
        Opsonization
        
        protein corona
        
        attract and attach to MPS
        
        NP got killed
        
        masks target ligands
        
        Reduce NP efficiency
        
        Solution
        
        Size
        
        1nm - 100nm
        
        2 more items...
        
        Surface
        
        PEGylation coatings
        
        Surface functional group
        
        Surface charge
        
        targeting ligand
        
        Shape
        
        Sphere
        
        Cube
        
        Rod
        
        Plate
        
        Star
        
        Material
      - In vivo
        
        Ingesttion
        
        Inhalation
        
        Skin
        
        Intravenous
        
        Intraperitonial
        
        Intracerebroventricular
- - - - MRI
      - CT
    - - PET
      - SPECT
  - - - Involuntary
        
        Organ Motion
        
        Cardiac
        
        Respiratory
        
        Organ/Tumour Motion
        
        Head/Body Motion
        
        Reflex
        
        Tremors
      - Voluntary
        
        Head/Body motion
        
        Discomfort
        
        Non Compliance
        
        Anxiety
      - Implications
        
        Blurring
        
        Streaking
        
        Ghosting
        
        Contrast Loss
        
        Resolution Loss
        
        Noise
      - Motion Artifacts Dependencies
        
        Amplitude
        
        Duration
        
        Velocity
        
        Periodic/Random
        
        Rigid/Non Rigid
      - Preventing
        
        Invasive
        
        Stereostatic Frame
        
        Surgical fixations
        
        Non-Invasive
        
        Thermo-plastic mask
        
        Sedation/ Anaesthesia / Paralysis
      - Correction
        
        Excluding corrupted data
        
        Image Registration
        
        Gating
        
        Deconvolution (Deblurring)
        
        Data Driven Approaches
        
        Event-by-event based compensation
- - - - Cells + Scaffolds
        
        Cell proliferation , ECM deposition + Scaffold Degradation
    - - Cell-encapsulating microgels
        
        Tissue building blocks
        
        Random Assembly
        
        Directed Assembly
        
        Stacking
        
        Magnetic Assembly
      - Cell Aggregation
      - Cell Sheet
      - Cell Printing
- - - - Whistleblowing
      - Corporate responsibilities and loyalties
      - Beware of groupthink
      - Falsifying records
      - Respecting intellectual property
    - - Environmental Responsibility
      - Techno responsibility
      - Social Responsibility
    - - Utilitarianism
      - Duty Ethics
      - Virtue Ethics
      - Ethical Egoism
        
        Different Codes supported by different Theories
      - Right Ethics
    - - To demonstrate integrity
      - To practice competently
      - To exercise leadership
      - To promote support sustainability
- - - - Scan region of interest
      - Obtain material properties for tissues and implants
      - Estimate expected loads
    - - Generate appropriate mesh
      - Characterise interaction between anatomy and prosthesis
      - Verify Stimulation results and prosthesis designs
      - Inputs
        
        Material Properties
        
        Loads
        
        Gait analysis results
        
        Boundary conditions
        
        Geometry
    - - Combine with CAD model of prosthesis
      - Segmentation
        
        Import image stack
        
        Separate into different tissues types/parts
        
        Smooth filter, FIt curves
        
        Create surface model
        
        Generate solid model
- - - - hydrodynamics
      - laminar flow
        
        flows in parallel layers
      - turbulent flow
        
        unsteady vortices appear on many scales and interact with each other
    - - Junction
        
        T- junction
        
        Y-junction
        
        2 different fluids
        
        study the evolution of a reactions
        
        Capillary
        
        Flow focusing
        
        the size of droplet produced
      - Flow
        
        Continuous
        
        Segmented
    - - Cel encapsulation
      - Cell Sorting
      - Continuous Droplet PCR
      - Vascular Models
        
        replicate the structure and function of blood vessels
        
        investigation of endothelial cell responses to shear stress
        
        the formation of atherosclerotic plaques
        
        the behavior of circulating cells and immune cells in controlled flow conditions
      - Organ on chips
        
        models of the heart or blood vessels
        
        integrate human cells with microfluidic channel
        
        cardiomyocytes
        
        endothelial
        
        mimic physiological flow patterns and mechanical cues
- - - - Chronic Pain
      - Movement Disorder
        
        Parkinson Disorder
        
        Tremor
        
        Dystonia
      - Epilepsy
      - Hearing & Visual Impairment
        
        Cochlear Implants
        
        Retinal Implants
      - Psychiatric Disorder
        
        Depression
        
        Anziety
        
        OCD
    - - Electrical Stimulation
        
        delivering controlled electrical pulses to neural tissue using electrodes
        
        Deep Brain Stimulation (DBS)
        
        Spinal Cord Stimulation (SCS)
        
        Vagus Nerve Stimulation (VNS)
      - Chemical Stimulation
        
        use drugs or pharmaceutical agents to modulate neural activity.
        
        Medications
        
        Neuromodulatory substances