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Proteomics - Biomarkers - Coggle Diagram
Proteomics - Biomarkers
Biomarker
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Validity
Specificity - nu,ber of true negatives
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Challenges
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Genome → transcriptome → proteome.
Transcriptome becomes proteome after Post Translational Mod, most abundant of which is phosphorylation.
Expression of proteins regulated by phosphorylation resulting in dynamic range etc talk about phosphorylation.
Dysregulation of this results in range of proteins seen in cancer - EGFR mutation
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The assay needs to be very sensitive and specific because we are working in a very narrow concentration range
For example, many interleukins and cytokines are below the suitable minimal range of detection
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- Spatio-temporal Organisation
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Proteomics
Analysis of the expression, localisation, functions and interactions of proteins
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